Prion protein PrP (PRNP) Rabbit Monoclonal Antibody [Clone ID: R03-2E2]

CAT#: TA385060

Prion Protein Rabbit monoclonal Antibody

Product Images

Western blot detection of Prion protein in Rat Brain and Mouse Brain lysates using Prion Protein Rabbit mAb (1:1000 diluted).Predicted band size:28kDa.Observed band size:28kDa.

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  Immunohistochemistry of Prion protein in paraffin-embedded Human breast cancer tissue using Prion Protein Rabbit mAb at dilution 1/20

Specifications

Product Data

• Clone Name: R03-2E2
• Applications: IHC, WB
• Recommended Dilution: WB: 1/1000-1/5000
  IHC: 1/20
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human Prion protein PrP
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 28 kDa; Observed MW: 28 kDa
• Gene Name: prion protein
• Database Link:
  Entrez Gene 5621 Human
  UniProt ID P04156
• Background: Swiss-Prot Acc.P04156.Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) . Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains .
• Synonyms: AA960666; AI325101; CD230; Prn; Prn-i; Prn-p; PrP; prP27-30; prP33-35C; PrP; PrPC; PrPSc; Sinc