Epac1 (RAPGEF3) Rabbit Monoclonal Antibody [Clone ID: R05-6B2]

CAT#: TA385132

Epac1 Rabbit monoclonal Antibody

Product Images

Western blot detection of Epac1 in 3T3 cell lysates using Epac1 Rabbit mAb(1:1000 diluted).Predicted band size:104kDa.Observed band size:104kDa.

Specifications

Product Data

• Clone Name: R05-6B2
• Applications: IP, WB
• Recommended Dilution: WB: 1/2000
  IP: 1/20
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human Epac1
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 104 kDa; Observed MW: 104 kDa
• Gene Name: Rap guanine nucleotide exchange factor 3
• Database Link:
  Entrez Gene 10411 Human
  UniProt ID O95398
• Background: Swiss-Prot Acc.O95398.Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
• Synonyms: 9330170P05Rik; bcm910; CAMP-GEFI; CGEF1; EPAC; EPAC1; HSU79275; MGC21410