SCIN Rabbit Monoclonal Antibody [Clone ID: R07-6G2]

CAT#: TA385215

SCIN Rabbit monoclonal Antibody

Product Images

Western blot detection of SCIN in Hela cell lysates using SCIN Rabbit mAb(1:1000 diluted).Predicted band size:80kDa.Observed band size:80kDa.

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  Immunohistochemistry of SCIN in paraffin-embedded Human colon cancer tissue using SCIN Rabbit mAb at dilution 1/50

Specifications

Product Data

• Clone Name: R07-6G2
• Applications: IHC, WB
• Recommended Dilution: WB: 1/1000
  IHC: 1/50
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human SCIN
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 80 kDa; Observed MW: 80 kDa
• Gene Name: scinderin
• Database Link:
  Entrez Gene 85477 Human
  UniProt ID Q9Y6U3
• Background: Swiss-Prot Acc.Q9Y6U3.Ca2+-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) . In vitro, also has barbed end capping and nucleating activities in the presence of Ca2+. Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts . Regulates chondrocyte proliferation and differentiation . Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009).
• Synonyms: adseverin; KIAA1905; Scinderin