SCIN Rabbit Monoclonal Antibody [Clone ID: R07-6G2]

CAT#: TA385215

SCIN Rabbit monoclonal Antibody


USD 380.00

4 Weeks*

Size
    • 100 ul

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Specifications

Product Data
Clone Name R07-6G2
Applications IHC, WB
Recommended Dilution WB: 1/1000
IHC: 1/50
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Monoclonal
Immunogen A synthetic peptide of human SCIN
Formulation 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration lot specific
Purification Affinity Purified
Conjugation Unconjugated
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Stability 1 year
Predicted Protein Size Calculated MW: 80 kDa; Observed MW: 80 kDa
Gene Name scinderin
Background Swiss-Prot Acc.Q9Y6U3.Ca2+-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) . In vitro, also has barbed end capping and nucleating activities in the presence of Ca2+. Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts . Regulates chondrocyte proliferation and differentiation . Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009).
Synonyms adseverin; KIAA1905; Scinderin
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.