SQSTM1 Rabbit Polyclonal Antibody

CAT#: TA385312

SQSTM1/p62 Rabbit polyclonal Antibody

Product Images

Western blot analysis of p62/SQSTM1 expression in C2C12,THP-1,3T3,Jurkat and Hela cell lysates using p62/SQSTM1 antibody at 1/1000 dilution.Predicted band size:47KDa.Observed band size:62KDa.

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  Immunofluorescent analysis of Hela cells, using p62/SQSTM1 Antibody.

Specifications

Product Data

• Applications: FC, IF, WB
• Recommended Dilution: WB: 1/1000
  ICC/IF: 1/50-1/200
  FC: 1/50
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthesized peptide derived from human p62/SQSTM1
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: lot specific
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: 62kDa
• Gene Name: sequestosome 1
• Database Link:
  Entrez Gene 8878 Human
  UniProt ID Q13501
• Background: Swiss-Prot Acc.Q13501.Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1.
• Synonyms: A170; EBIAP; ORCA; OSIL; p60; p62; p62B; PDB3; ZIP3