Stromal interaction molecule 1 (STIM1) Rabbit Monoclonal Antibody [Clone ID: R07-9F9]

CAT#: TA385346

Stromal Interaction Molecule 1 Rabbit monoclonal Antibody

Product Images

Western blot detection of Stromal interaction molecule 1 in MCF7,C6,3T3,Hela cell lysates using Stromal interaction molecule 1 Rabbit mAb(1:1000 diluted).Predicted band size:77KDa.Observed band size:77KDa.

Specifications

Product Data

• Clone Name: R07-9F9
• Applications: WB
• Recommended Dilution: WB: 1/1000-1/5000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human Stromal interaction molecule 1
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 77 kDa; Observed MW: 77 kDa
• Gene Name: stromal interaction molecule 1
• Database Link:
  Entrez Gene 6786 Human
  UniProt ID Q13586
• Background: Swiss-Prot Acc.Q13586.Plays a role in mediating store-operated Ca2+ entry (SOCE), a Ca2+ influx following depletion of intracellular Ca2+ stores (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19249086, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:26322679, PubMed:25326555, PubMed:28219928). Acts as Ca2+ sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca2+ depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca2+ release-activated Ca2+ (CRAC) channel subunit ORAI1 (PubMed:16208375, PubMed:16537481). Involved in enamel formation (PubMed:24621671). Activated following interaction with STIMATE, leading to promote STIM1 conformational switch (PubMed:26322679).
• Synonyms: D11S4896E; GOK