Sumo 1 (SUMO1) Rabbit Monoclonal Antibody [Clone ID: R04-9G9]

CAT#: TA385361

SUMO1 Rabbit monoclonal Antibody

Product Images

Western blot detection of Sumo 1 in Hela cell lysates using Sumo 1 Rabbit mAb(1:1000 diluted).Predicted band size:12KDa.

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  Immunohistochemistry of Sumo 1 in paraffin-embedded Human lung cancer tissue using Sumo 1 Rabbit mAb at dilution 1/20

Specifications

Product Data

• Clone Name: R04-9G9
• Applications: IHC, WB
• Recommended Dilution: WB: 1/1000-1/5000
  IHC: 1/20-1/100
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human Sumo 1
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 12 kDa; Observed MW: _
• Gene Name: small ubiquitin-like modifier 1
• Database Link:
  Entrez Gene 7341 Human
  UniProt ID P63165
• Background: Swiss-Prot Acc.P63165.Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376).
• Synonyms: DAP-1; GMP1; OFC10; PIC1; SENP2; Sentrin; SMT3; SMT3C; SMT3H3; SUMO-1; UBL1