TCF7L2 Rabbit Polyclonal Antibody

CAT#: TA385382

Transcription Factor 7 Like 2 Rabbit polyclonal Antibody

Product Images

Immunohistochemical analysis of paraffin-embedded human colonic cancer, using TCF7L2 Antibody.

• 

  Western blot analysis of TCF7L2 expression in Jurkat cell lysate.

Specifications

Product Data

• Applications: FC, IF, IHC, IP, WB
• Recommended Dilution: WB: 1/1000
  IHC: 1/50-1/200
  ICC/IF: 1/50-1/200
  IP: 1/50
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthesized peptide derived from human TCF7L2
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: lot specific
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: 68kDa
• Gene Name: transcription factor 7 like 2
• Database Link:
  Entrez Gene 6934 Human
  UniProt ID Q9NQB0
• Background: Swiss-Prot Acc.Q9NQB0.Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1.
• Synonyms: hTCF-4; TCF-4; TCF4