TCF7L2 Rabbit Monoclonal Antibody [Clone ID: R09-1D1]

CAT#: TA385383

Transcription Factor 7 Like 2 Rabbit monoclonal Antibody


USD 380.00

4 Weeks*

Size
    • 100 ul

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Specifications

Product Data
Clone Name R09-1D1
Applications IHC, IP, WB
Recommended Dilution WB: 1/1000
IHC: 1/50
IP: 1/20
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Monoclonal
Immunogen A synthetic peptide of human TCF-4
Formulation 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration lot specific
Purification Affinity Purified
Conjugation Unconjugated
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Stability 1 year
Predicted Protein Size Calculated MW: 68 kDa; Observed MW: 68 kDa
Gene Name transcription factor 7 like 2
Background Swiss-Prot Acc.Q9NQB0.Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small inTine.
Synonyms hTCF-4; TCF-4; TCF4
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.