TCF7L2 Rabbit Monoclonal Antibody [Clone ID: R09-1D1]

CAT#: TA385383

Transcription Factor 7 Like 2 Rabbit monoclonal Antibody

Product Images

Western blot analysis of TCF4 in K562, Hela lysates using Transcription Factor 7 Like 2 antibody.

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  Immunohistochemistry analysis of paraffin-embedded Human Cholangiocarcinoma using TCF4 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Specifications

Product Data

• Clone Name: R09-1D1
• Applications: IHC, IP, WB
• Recommended Dilution: WB: 1/1000
  IHC: 1/50
  IP: 1/20
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human TCF-4
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 68 kDa; Observed MW: 68 kDa
• Gene Name: transcription factor 7 like 2
• Database Link:
  Entrez Gene 6934 Human
  UniProt ID Q9NQB0
• Background: Swiss-Prot Acc.Q9NQB0.Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small inTine.
• Synonyms: hTCF-4; TCF-4; TCF4