CD71 (TFRC) Rabbit Monoclonal Antibody [Clone ID: R08-6H2]

CAT#: TA385393

Transferrin Receptor 1 Rabbit monoclonal Antibody

Product Images

Western blot detection of Transferrin Receptor in K562,Hela cell lysates using Transferrin Receptor Rabbit mAb(1:1000 diluted).Predicted band size:84kDa.Observed band size:90kDa.

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  Immunocytochemistry of Transferrin Receptor(green) in Hela cells using Transferrin Receptor Rabbit mAb at dilution 1/200, and DAPI(blue)

Specifications

Product Data

• Clone Name: R08-6H2
• Applications: IF, IP, WB
• Recommended Dilution: WB: 1/1000
  ICC/IF: 1/20
  IP: 1/20
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Recombinant protein of human Transferrin Receptor
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 84 kDa; Observed MW: 90 kDa
• Gene Name: transferrin receptor
• Database Link:
  Entrez Gene 7037 Human
  UniProt ID P02786
• Background: Swiss-Prot Acc.P02786.Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system . A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).
• Synonyms: CD71; p90; T9; TfR; TfR1; TR; Trfr