STING (TMEM173) Rabbit Polyclonal Antibody

CAT#: TA385419

Transmembrane Protein 173 Rabbit polyclonal Antibody

Product Images

Western blot analysis of extracts from 3T3 cells using STING Rabbit pAb at 1:1000 dilution. Predicted band size: 42kDa. Observed band size: 39kDa.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1/1000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Purified recombinant mouse STING protein fragments expressed in E.coli
• Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.03% Proclin 300, pH 7.3.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: 42kDa
• Gene Name: transmembrane protein 173
• Database Link:
  Entrez Gene 340061 Human
  UniProt ID Q86WV6
• Background: Swiss-Prot Acc.Q86WV6/Q3TBT3.Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
• Synonyms: ERIS; FLJ38577; hMITA; hSTING; MITA; MPYS; NET23; STING