TSG101 Rabbit Monoclonal Antibody [Clone ID: R01-4D9]

CAT#: TA385476

TSG101 Rabbit monoclonal Antibody

Product Images

Western blot detection of TSG101 in K562,Rat Brain,C6,3T3,Hela cell lysates using TSG101 Rabbit mAb(1:1000 diluted).Predicted band size:44kDa.Observed band size:44kDa.

Specifications

Product Data

• Clone Name: R01-4D9
• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1/1000
  IHC: 1/100
  ICC/IF: 1/20
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human TSG101
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 44 kDa; Observed MW: 44 kDa
• Gene Name: tumor susceptibility 101
• Database Link:
  Entrez Gene 7251 Human
  UniProt ID Q99816
• Background: Swiss-Prot Acc.Q99816.Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426).
• Synonyms: TSG10; VPS23