Kaiso (ZBTB33) Rabbit Monoclonal Antibody [Clone ID: R05-5J5]

CAT#: TA385587

Kaiso Rabbit monoclonal Antibody

Product Images

Western blot detection of Kaiso in MCF7,C6 cell lysates using Kaiso Rabbit mAb(1:1000 diluted).Predicted band size:75KDa.Observed band size:90KDa.

Specifications

Product Data

• Clone Name: R05-5J5
• Applications: WB
• Recommended Dilution: WB: 1/1000-1/5000
• Reactivities: Human, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human Kaiso
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 75 kDa; Observed MW: 90 kDa
• Gene Name: zinc finger and BTB domain containing 33
• Database Link:
  Entrez Gene 10009 Human
  UniProt ID Q86T24
• Background: Swiss-Prot Acc.Q86T24.Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453).
• Synonyms: KAISO; WUGSC:H_DJ525N14.1; ZNF-kaiso; ZNF348