Paxillin (PXN) Rabbit Monoclonal Antibody [Clone ID: LD2 sAB]

CAT#: TA385938

Recombinant Anti-Paxillin (LD2 Motif) (Clone LD2 sAB)

Specifications

Product Data

• Clone Name: LD2 sAB
• Applications: ELISA, WB
• Reactivities: Human
• Modifications: This full-length, chimeric rabbit antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques.
• Host: Rabbit
• Isotype: IgG, kappa
• Clonality: Monoclonal
• Immunogen: Peptide corresponding to paxillin-LD2 motif (residues 141-156) fused to MBP; peptide sequence: NLSELDRLLLELNAVQHNP.
• Specificity: The antibody binds specifically to the LD-2 motif of human paxillin with a Kd of 24 nM.
  
  This antibody binds to the LD2-motif of human paxillin, a signal transduction adaptor protein involved in focal adhesion, with binding partners including integrins, Src, FAK or actin complexes. The antibody inhibits complex formation between paxillin and FAK. Paxillin is involved in both inside-out cell signalling and outside-to-inside cell signalling.
• Formulation: PBS with 0.02% Proclin 300.
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
• Stability: 3 years from dispatch.
• Gene Name: paxillin
• Database Link:
  Entrez Gene 5829 Human
  UniProt ID P49023
• Synonyms: FLJ16691; paxillin