TrkA (NTRK1) Rabbit Monoclonal Antibody [Clone ID: MNAC13]

CAT#: TA385960

Recombinant Anti-TrkA (Clone MNAC13)

Specifications

Product Data

• Clone Name: MNAC13
• Applications: Bl, ELISA, IHC
• Reactivities: Human
• Modifications: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
• Host: Rabbit
• Isotype: IgG, kappa
• Clonality: Monoclonal
• Immunogen: Human TrkA ECD.
• Specificity: This antibody binds to the extracellular domain of TrkA. It was shown not to cross react with TrkB . Moreover MNAC13 is specific to TrkA with negligible reactivity to TrkB and TrkC.
  
  This antibody binds to human TrkA, a receptor tyrosine kinase involved in the development and the maturation of the CNS and the PNS through regulation of proliferation, differentiation, and survival of the sympathetic and nervous neurons. It is a receptor for NGF and phosphorylates several downstream proteins regulating a variety of signalling cascades. This antibody neutralizes the NGF-TrkA interation.
• Formulation: PBS with 0.02% Proclin 300.
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
• Stability: 3 years from dispatch.
• Gene Name: neurotrophic receptor tyrosine kinase 1
• Database Link:
  Entrez Gene 4914 Human
  UniProt ID P04629
• Synonyms: DKFZp781I14186; MTC; p140-TrkA; TRK; Trk-A; TRK1; TRKA