CD40L (CD40LG) Mouse Monoclonal Antibody [Clone ID: hu5c8 (Ruplizumab)]

CAT#: TA385962

Recombinant Anti-CD40L (Clone hu5c8 (Ruplizumab))


USD 523.00

5 Weeks*

Size
    • 200 ug

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Specifications

Product Data
Clone Name hu5c8 (Ruplizumab)
Applications FC, WB
Reactivities Human
Modifications This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Host Mouse
Isotype IgG2a, kappa
Clonality Monoclonal
Immunogen Human CD40L
Specificity The antibody binds to CD40L with an IC50 of 0.845 ug/ml.

The antibody binds specifically to CD40L, a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. The antibody neutralises CD40L function, as it blocks the interaction between CD40 and CD40L. When injected into cynomolgus monkeys, the original therapeutic antibody was found to have a T1/2 of 531  ± 155 hours.
Formulation PBS with 0.02% Proclin 300.
Concentration lot specific
Conjugation Unconjugated
Storage Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Stability 3 years from dispatch.
Gene Name CD40 ligand
Synonyms CD40-L; CD40L; CD154; gp39; hCD40L; HIGM1; IGM; IMD3; T-BAM; TNFSF5; TRAP
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.