Folr2 Rat Monoclonal Antibody [Clone ID: CL10]

CAT#: TA385992

Recombinant Anti-Folate receptor beta (Clone CL10)

Specifications

Product Data

• Clone Name: CL10
• Applications: IHC, WB
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2a, kappa
• Clonality: Monoclonal
• Immunogen: FRβ_x0001_-transfected RBL2H3 cells.
• Specificity:
  
  The antibody binds specifically to FRβ, a member of the folate receptor family. The receptor binds with high affinity to folic acid and folic acid derivatives, and transports 5-methyltetrahydrofolate into the cell. The receptor is expressed on the surface of tumour associated macrophages (TAMs) that promote growth and metastasis of tumours such as gliomas and colon, breast and lung carcinomas. Research has shown FRβ is only expressed on activated macrophages, and thereby a monoclonal antibody that targets the receptor can be useful in the diagnosis of the cancer. Furthermore, the antibody may be conjugated with a toxin, delivering the drug only to TAMs and not to healthy macrophages.
• Formulation: PBS with 0.02% Proclin 300.
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
• Stability: 3 years from dispatch.
• Gene Name: folate receptor 2 (fetal)
• Database Link:
  Entrez Gene 14276 Mouse
  UniProt ID Q05685
• Synonyms: BETA-HFR; FBP; FBP/PL-1; FR-BETA; FR-P3