TNF alpha (TNF) Rabbit Monoclonal Antibody [Clone ID: D2E7 (Adalimumab)]

CAT#: TA386074

Recombinant Anti-TNF alpha (Clone D2E7 (Adalimumab))


USD 523.00

2 Weeks*

Size
    • 200 ug

Product Images

Specifications

Product Data
Clone Name D2E7 (Adalimumab)
Applications ELISA, IF, IHC
Reactivities Human
Modifications NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric rabbit antibody was made using the variable domain sequences of the original human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Host Rabbit
Isotype IgG, kappa
Clonality Monoclonal
Immunogen This antibody was generated by affinity maturation from the 2SD4 scFv, which in turn was selected on human TNF alpha by guided phage-display technology, using the murine anti-hTNF alpha antibody Mab32 as a template (c.f. also US Patent 6090382).
Specificity Binds to soluble TNF-alpha, but not to lymphotoxin (TNF beta).

Adalimumab binds specifically to TNF and neutralizes the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab, unlike Infliximab (Ab00146), was shown to be cross-reactive with mouse TNF alpha (Arnoult 2017, PMID: 28584008).
Formulation PBS with 0.02% Proclin 300.
Concentration lot specific
Conjugation Unconjugated
Storage Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Stability 3 years from dispatch.
Gene Name tumor necrosis factor
Synonyms Cachectin; DIF; TNF-a; TNF-alpha; TNFA; TNFSF2
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.