Tnfsf11 Rabbit Monoclonal Antibody [Clone ID: IK22-5]

CAT#: TA386258

Recombinant Anti-RANKL (Clone IK22-5)


USD 523.00

2 Weeks*

Size
    • 200 ug

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Specifications

Product Data
Clone Name IK22-5
Applications FC, IHC, Neutralize
Reactivities Mouse
Modifications This chimeric rabbit antibody was made using the variable domain sequences of the original rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.
Host Rabbit
Isotype IgG, kappa
Clonality Monoclonal
Immunogen Thus antibody was raised by immunising an SD rat with murine RANKL-transfected baby hamster kidney cells.
Specificity This antibody is specific for murine RANKL.

This antibody has been used in immunohistochemical analysis of frozen Peyer's patch tissue sections (Kobayashi et al, 2013). It has also been used in flow cytometric analysis of RANKL cell surface expression by Th1 and Th17 cells (Nakae et al, 2007), RANKL-transfected human embryonic kidney cells (Miyahira et al, 2003) and murine T hybridoma 2B4.11 cells (Fionda et al, 2007). Additionally, this RANKL-neutralising antibody has been used to assess the effects of RANKL inhibition on myoepithelial cell proliferation in mammary organoid culture (Haslam et al, 2008). Treatment of collagen-induced arthritis (CIA) mice with this antibody has been shown to reduce bone loss at the site of inflammation (Kamijo et al, 2006), while administration to C57BL/6J mice induced transient tibia and skull bone growth arrest and irreversible blockage of tooth eruption (Lezot et al, 2015).
Formulation PBS with 0.02% Proclin 300.
Concentration lot specific
Conjugation Unconjugated
Storage Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Stability 3 years from dispatch.
Gene Name tumor necrosis factor (ligand) superfamily, member 11
Synonyms CD254; hRANKL2; ODF; OPGL; OPTB2; OTTHUMP00000178585; RANKL; sOdf; TRANCE
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.