CD43 (SPN) Mouse Monoclonal Antibody [Clone ID: 84-3C1]
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Specifications
Product Data | |
Clone Name | 84-3C1 |
Applications | FC, IF, IHC, IP, WB |
Reactivities | Human |
Host | Mouse |
Isotype | IgG2b, kappa |
Clonality | Monoclonal |
Immunogen | This antibody was raised by immunizng mice with stimulated human leukocytes. |
Specificity | This antibody recognizes CD43 which is a predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. This antibody can be used in the identification of malignant lymphomas. CD43 is expressed on 22-37% of B-cell lymphomas and, at the same time, it is not expressed on reactive B-cells. Consequently, B-lineage population that co-expresses CD43 is highly likely to be a malignant lymphoma. If used with an anti-CD20 antibody, this clone may be utilized in the immunophenotyping of the lymphomas in formalin-fixed tissues, as Co-staining of a lymphoid infiltrate with anti-CD20 and anti-CD43 usually indicates lymphoma. Importantly, 84-3C1 antibody can be used for the detection of CD43 via various methods. For instance, it was successful in indetifying that antigen in a lysate of dendritic cells' platellet via Western blot (Julien et al., 2007). Finally, another group used this antibody during flow cytometric analysis a sample of B-cells (Yoon et al., 2017). |
Formulation | PBS with 0.02% Proclin 300. |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage | Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles. |
Stability | 3 years from dispatch. |
Gene Name | sialophorin |
Database Link | |
Synonyms | CD43; Galactoglycoprotein; GALGP; GPL115; leukosialin; LSN; Sialophorin |
Reference Data |
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