CEACAM5 Rabbit Monoclonal Antibody [Clone ID: BW431/26]
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Specifications
Product Data | |
Clone Name | BW431/26 |
Reactivities | Human |
Modifications | This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG3 format, for improved compatibility with existing reagents, assays and techniques. |
Host | Rabbit |
Isotype | IgG, kappa |
Clonality | Monoclonal |
Immunogen | The original antibody was generated by immunizing mice with CEA positive adenocarcinoma cells preferably from lungs. |
Specificity | This antibody recognizes and binds human carcinoembryonic antigen in its purified state as well as on tissue sections. Technetium 99-labeled (Tc-99m) BW431/26 has been used in the diagnosis and detection of colorectal carcinomas, breast cancers, bladder carcinomas, lung adenocarcinomas and their recurrences by immunoscintigraphy (PMID: 2602902, 2662074, 2685692, 2297747, 2157833, 2166552, 2383485, 1984945 ). The use of Tc-99m-BW 431/26 immunoconjugates in immunoscintigraphy resulted in reduction of radiation dose for the patient down to 5% of the dose applied as compared with I-131 labelled MAbs (PMID: 3262953). Humanized version of this antibody also shows similar binding affinity as compared to its murine parent antibody (PMID: 1762576). |
Formulation | PBS with 0.02% Proclin 300. |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage | Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles. |
Stability | 3 years from dispatch. |
Gene Name | carcinoembryonic antigen related cell adhesion molecule 5 |
Database Link | |
Synonyms | CD66e; CEA; DKFZp781M2392; OTTHUMP00000199034 |
Reference Data |
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