Mesothelin (MSLN) Mouse Monoclonal Antibody [Clone ID: 11-25]
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Specifications
Product Data | |
Clone Name | 11-25 |
Applications | ELISA, FC, IP |
Reactivities | Human |
Host | Mouse |
Isotype | IgG2b, kappa |
Clonality | Monoclonal |
Immunogen | The original antibody was generated by intraperitoneally immunizing BALB/c mice with the purified recombinant mesothelin protein. |
Specificity | This antibody binds the human mesothelin protein which is highly expressed in many human cancers, including the majority of pancreatic adenocarcinomas, ovarian cancers, and mesotheliomas. This antibody is recommended to be used in combination with mAb IC14-30 for detecting mesothelin with high sensitivity in a capture ELISA. This antibody can also immunoprecipitate recombinant mesothelin. NCI-H226 and NCI-H520 were incubated with anti-MSLN antibodies (11—25 ) or an isotype-matched control antibody and followed by PE-conjugate anti mouse IgG. Antigen expression was detected by flow cytometry (PMID: 18394747). 64Cu labelled 11-25 was used in vitro cell binding assay and in vivo positron emission tomography (PET) imaging in the tumor-bearing mice (PMID: 25883990). |
Formulation | PBS with 0.02% Proclin 300. |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage | Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles. |
Stability | 3 years from dispatch. |
Gene Name | mesothelin |
Database Link | |
Synonyms | CAK1; mesothelin; MPF; SMR |
Reference Data |
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