PD-L1 (CD274) Human Monoclonal Antibody [Clone ID: 332M7]

CAT#: TA386530

Recombinant Anti-PD-L1 (Clone 332M7)

Specifications

Product Data

• Clone Name: 332M7
• Applications: FC
• Reactivities: Human, Monkey, Mouse
• Host: Human
• Isotype: IgG1, kappa
• Clonality: Monoclonal
• Immunogen: The original antibody was generated by immunizing BALB/c mice with recombinant human PD-L1.
• Specificity: This antibody strongly binds human and cynomolgus monkey PD-L1 and shows weak binding for mouse PD-L1. PD-L1 is highly expressed in many human tumors. . PD-L1 exerts an immune suppressive signal through binding to PD-1 and B7.1, and tumor expression of PD-L1 can mediate cancer immune evasion. Blocking this pathway, therefore provides a rationale for cancer immunotherapy.
  
  The binding characterization of this antibody towards human, mouse and cynomolgus monkey PD-L1 was done using flow cytometry. This antibody was shown to block the binding of hPD-1-Fc protein to hPD-L1 expressed on the surface of the HEK-293T cells at a concentration of 10 μg/ml. The mouse version of this antibody was reported to inhibit patient derived melanoma tumor in tumor-bearing mice. There was also found an increase in the gene expression of CD8 and IFN-γ in tumor samples from mice treated with mouse version of this antibody (US20180346571).
• Formulation: PBS with 0.02% Proclin 300.
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
• Stability: 3 years from dispatch.
• Gene Name: CD274 molecule
• Database Link:
  Entrez Gene 29126 Human
  UniProt ID Q9NZQ7
• Synonyms: B7-H; B7-H1; B7H1; MGC142294; MGC142296; PD-L1; PDCD1L1; PDCD1LG1; PDL1