alpha Synuclein (SNCA) Mouse Monoclonal Antibody [Clone ID: 2A7]

CAT#: TA388991

Anti-Alpha Synuclein Antibody

Specifications

Product Data

• Clone Name: 2A7
• Applications: ICC, IHC, WB
• Recommended Dilution: WB: 1:1000
  WB Brain: 1:1000
  ICC: 1:1000
• Reactivities: Bovine, Human, Mouse, Rat, Pig
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Full length human alpha synuclein expressed in E. Coli.
• Specificity: Specific for the endogenous levels of the ~15 kDa alpha synuclein protein.
• Formulation: PBS + 50% glycerol and 5 mm NaN3
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
• Stability: After date of receipt, stable for at least 1 year at -20°C.
• Predicted Protein Size: 15
• Gene Name: synuclein alpha
• Database Link:
  Entrez Gene 6622 Human
  UniProt ID P37840
• Background: Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson’s disease (PD) and other neurodegenerative disorders (Okochi et al., 2000). Early onset Parkinson's disease may be caused by a duplication or triplication of one of the alpha synuclein genes (ChartierHarlin MC et al., 2004 and Singleton, AB et al., 2005). Alpha-synuclein is also found in the Lewy bodies of patients with diffuse Lewy body disease and inclusions in glial cells in the brains of patients with multiple system atrophy (MSA) and amyotrophic lateral sclerosis (ALS).
• Synonyms: alpha-synuclein; MGC110988; NACP; OTTHUMP00000161559; OTTHUMP00000161561; PARK1; PARK4; PD1
• Note: Protein G purified.