Lamin A (LMNA) Mouse Monoclonal Antibody [Clone ID: 4C4]

CAT#: TA389014

Anti-Lamin A/C Antibody

Specifications

Product Data

• Clone Name: 4C4
• Applications: ICC, IHC, WB
• Recommended Dilution: WB: 1:5000
  ICC: 1:1000
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant full length human lamin C expressed in and purified from E. Coli.
• Specificity: Specific for endogenous levels of the ~64 kDa and ~74 kDa lamin A and C proteins.
• Formulation: PBS + 10 mM NaN3.
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.
• Stability: After date of receipt, stable for at least 1 year at -20°C.
• Predicted Protein Size: 64, 74
• Gene Name: lamin A/C
• Database Link:
  Entrez Gene 4000 Human
  UniProt ID P02545
• Background: Lamins A and C are nuclear structural proteins that are part of the intermediate filament family and coded for by the same gene (LMNA). Lamins A and C are nearly identical except for their carboxy termini (McKeon et al., 1986). Mutations in the gene encoding lamins A/C have been shown to cause a variety of diseases including autosomal dominant Emery-Dreifuss muscular dystrophy (Bonne et al., 1995), autosomal dominant limbgirdle muscular dystrophy (Muchir et al., 2000) and Charcot-Marie-Tooth disorder type 2 (De Sandre-Giavonnoli et al., 2002).
• Synonyms: CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC; OTTHUMP00000015843; PRO1
• Note: Protein G purified culture supernatant