MAPKAP Kinase 2 (MAPKAPK2) Rabbit Polyclonal Antibody

CAT#: TA392566

MAPKAPK-2 (Phospho-T334) polyclonal antibody


USD 285.00

4 Weeks*

Size
    • 100 ul

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Specifications

Product Data
Applications IF, WB
Recommended Dilution WB: 1:2000~1:5000 IF: 1:50~1:200
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic phosphopeptide derived from human MAPKAPK-2 around the phosphorylation site of Threonine 334.
Specificity MAPKAPK-2 (Phospho-T334) polyclonal antibody detects endogenous levels of MAPKAPK-2 protein only when phosphorylated at Thr334.
Formulation Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Concentration 1mg/ml
Conjugation Unconjugated
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Stability 1 year
Predicted Protein Size ~ 48 kDa
Gene Name mitogen-activated protein kinase-activated protein kinase 2
Background In response to cytokines, stress, and chemotactic factors, MAP kinase-activated protein kinase 2 (MAPKAPK-2) is rapidly phosphorylated and activated. It has been shown that MAPKAPK-2 is a direct target of p38 MAPK. Multiple residues of MAPKAPK-2 are phosphorylated in vivo in response to stress. However, only four residues (Thr25, Thr222, Ser272, and Thr334) are phosphorylated by p38 MAPK in an in vitro kinase assay. Phosphorylation at Thr222, Ser272, and Thr334 appears to be essential for the activity of MAPKAPK-2. Thr25 is phosphorylated by p42 MAPK in vitro, but is not required for the activation of MAPKAPK-2.
Synonyms MAPK-activated protein kinase 2; MAPKAP-K2; MAPKAPK-2; MAPKAPK2; MAPKAP kinase 2; MAP kinase-activated protein kinase 2; MK-2; MK2
Note For research use only, not for use in diagnostic procedure.
Reference Data

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