DARPP32 (PPP1R1B) Rabbit Polyclonal Antibody

CAT#: TA392887

DARPP-32 (phospho-T75) polyclonal antibody


USD 285.00

4 Weeks*

Size
    • 100 ul

Product Images

Other products for "PPP1R1B"

Specifications

Product Data
Applications WB
Recommended Dilution WB: 1:500~1:1000 IHC: 1:50~1:200
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic phosphopeptide derived from human DARPP-32 around the phosphorylation site of Threonine 75.
Specificity p-DARPP-32 (T75) polyclonal antibody detects endogenous levels of DARPP-32 protein only when phosphorylated at Thr75
Formulation Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration 1mg/ml
Conjugation Unconjugated
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Stability 1 year
Predicted Protein Size ~ 32 kDa
Gene Name protein phosphatase 1 regulatory inhibitor subunit 1B
Background Dopaminergic signaling pathways, which are essential for multiple brain functions, are abnormal in several neurological disorders, such as schizophrenia, Parkinson’s disease and drug abuse. DARPP-32 (for dopamine and adenosine 3’,5’-monophosphate-regulated phosphoprotein of 32 kDa) is abundant in neurons that receive dopaminergic input. Activation of PKA and the consequent phosphorylation of DARPP-32 on threonine occurs in response to dopamine acting upon D1-like receptors. Dopamine interaction with D2-like receptors results in the inhibition of PKA activation, the activation of protein phosphatase 2B and the consequent dephosphorylation of DARPP-32. Neurotransmitters other than dopamine may also be able to stimulate the phosphorylation or dephosphorylation of DARPP-32. Phosphorylated DARPP-32 is a potent inhibitor of PP-1.
Synonyms DARPP-32; DARPP32; Dopamine- and cAMP-regulated neuronal phosphoprotein; PPP1R1B; Protein phosphatase 1 regulatory subunit 1B
Note For research use only, not for use in diagnostic procedure.
Reference Data

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.