Cytokeratin 18 (KRT18) Rabbit Polyclonal Antibody

CAT#: TA392892

Cytokeratin 18 (phospho-S33) polyclonal antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500~1:1000 IHC: 1:50~1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic phosphopeptide derived from human Cytokeratin 18 around the phosphorylation site of Serine 33.
• Specificity: p-Cytokeratin 18 (S33) polyclonal antibody detects endogenous levels of Cytokeratin 18 protein only when phosphorylated at Ser33.
• Formulation: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Concentration: 1mg/ml
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
• Stability: 1 year
• Predicted Protein Size: ~ 46 kDa
• Gene Name: keratin 18
• Database Link:
  Entrez Gene 3875 Human
  UniProt ID P05783
• Background: Cytokeratin 18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.Involved in the uptake of thrombin-antithrombin complexes by hepatic cells By similarity. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
• Synonyms: Cell proliferation-inducing gene 46 protein; CK-18; CK 18; CK18; CYK18; Cytokeratin-18; Keratin, type I cytoskeletal 18; Keratin-18; Keratin 18; Keratin18; KRT 18; KRT18; PIG46; Short name=CK-18; Short name=K18
• Note: For research use only, not for use in diagnostic procedure.