WNK1 Rabbit Polyclonal Antibody

CAT#: TA392897

WNK1 (phospho-T60) polyclonal antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500~1:1000 IHC: 1:50~1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic phosphopeptide derived from human WNK1 around the phosphorylation site of Threonine 60.
• Specificity: p-WNK1 (T60) polyclonal antibody detects endogenous levels of WNK1 protein only when phosphorylated at Thr60.
• Formulation: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Concentration: 1mg/ml
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
• Stability: 1 year
• Predicted Protein Size: ~ 251 kDa
• Gene Name: WNK lysine deficient protein kinase 1
• Database Link:
  Entrez Gene 65125 Human
  UniProt ID Q9H4A3
• Background: WNK1 (WNK lysine deficient protein kinase 1), also known as KDP (kinase deficient protein), PSK, erythrocyte 65 kDa protein (p65), HSN2, HSAN2 or PRKWNK1, is a 2,382 amino acid cytoplasmic protein that participates in cell signaling, proliferation and survival, and regulates electrolyte homeostasis. WNK1 belongs to the Ser/Thr protein kinase family of the protein kinase superfamily, and contains one protein kinase domain. Existing as five alternatively spliced isoforms, WNK1 is widely expressed but is found at highest levels in skeletal muscke, heart, testis and kidney. The gene that encodes WNK1 maps to human chromosome 12p13.33, and when defective, is the cause of an an autosomal dominant disease known as pseudohypoaldosteronism type II (PHAII), as well as a hereditary sensory and autonomic neuropathy designated hereditary sensory and autonomic neuropathy type 2A (HSAN2A).
• Synonyms: Erythrocyte 65 kDa protein; HSN2; hWNK1; KDP; KIAA0344; Kinase deficient protein; PRKWNK1; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1; Serine/threonine-protein kinase WNK1; WNK
• Note: For research use only, not for use in diagnostic procedure.