Dynamin 1 (DNM1) Rabbit Polyclonal Antibody

CAT#: TA392903

Dynamin-1 (phospho-S774) polyclonal antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500~1:1000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic phosphopeptide derived from human Dynamin-1 around the phosphorylation site of Serine 774.
• Specificity: p-Dynamin-1 (S774) polyclonal antibody detects endogenous levels of Dynamin-1 protein when phosphorylated at Ser774.
• Formulation: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Concentration: 1mg/ml
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
• Stability: 1 year
• Predicted Protein Size: ~ 98 kDa
• Gene Name: dynamin 1
• Database Link:
  Entrez Gene 1759 Human
  UniProt ID Q05193
• Background: Members of the Dynamin family, including Dynamin I and Dynamin II, are GTPase, microtubule-associated proteins which are involved in endocytosis, synaptic transmission and neurogenesis. Dynamin I is localized to the central nervous system, while Dynamin II exhibits ubiquitous distribution with highest expression in testis. Both Dynamin proteins contain SH3 and proline-rich domains that mediate interactions between the Dynamins and effectors of their GTPase activity. The interactions with these effectors, which include microtubules, acidic phospholipids and SH3 domain-containing proteins, are required for rapid endocytosis. Dynamin I appears to be recruited to Clathrin coated pits by SH3 domain interaction with Amphiphysin, a protein highly expressed in brain.
• Synonyms: DNM; DNM1; Dynamin-I; Dynamin 1; Dynamin1; Dynamin I; DynaminI
• Note: For research use only, not for use in diagnostic procedure.