Insulin Receptor (INSR) Rabbit Polyclonal Antibody

CAT#: TA392914

Insulin Receptor (phospho-Y1355) polyclonal antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500~1:1000 IHC: 1:50~1:200
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic phosphopeptide derived from human Insulin Receptor around the phosphorylation site of Tyrosine 1355.
• Specificity: p-Insulin Receptor (Y1355) polyclonal antibody detects endogenous levels of Insulin Receptor protein only when phosphorylated at Tyr1355.
• Formulation: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Concentration: 1mg/ml
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
• Stability: 1 year
• Predicted Protein Size: ~ 156 kDa
• Gene Name: insulin receptor
• Database Link:
  Entrez Gene 3643 Human
  UniProt ID P06213
• Background: The insulin receptor (IR) is a heterodimeric protein complex that has an intracellular β subunit and an extracellular α subunit, which is disulfide- linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intracellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin.
• Synonyms: CD220; INSR; Insulin receptor; IR
• Note: For research use only, not for use in diagnostic procedure.