EGFR Rabbit Polyclonal Antibody
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Other products for "EGFR"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200 |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Synthetic phosphopeptide derived from human EGFR around the phosphorylation site of Tyrosine 992. |
Specificity | p-EGFR (Y992) polyclonal antibody detects endogenous levels of EGFR protein only when phosphorylated at Tyr992 (removal of the signal peptide). |
Formulation | Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
Concentration | 1mg/ml |
Conjugation | Unconjugated |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
Stability | 1 year |
Predicted Protein Size | ~ 175 kDa |
Gene Name | epidermal growth factor receptor |
Database Link | |
Background | Epidermal growth factor mediates its effects on cell growth through its interaction with a cell surface glycoprotein designated the EGF receptor. Binding of EGF or TGFα to the EGF receptor activates tyrosine-specific protein kinase activity intrinsic to the EGF receptor. The carboxy-terminal tyrosine residues on EGFR, Tyr 1068 and Tyr 1173, are the major sites of autophosphorylation, which occurs as a result of EGF binding. Phosphorylation of Tyr 992, Tyr 1068 and Tyr 1086 is required for conformational change in the C-terminal tail of the EGF receptorgulates Actin filament accumulation at the plasma membrane and Cdc42 stimulates formation of filopodia. |
Synonyms | EC=2.7.10.1; EGFR; Epidermal growth factor receptor; ERBB; ERBB1; HER1; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1 |
Note | For research use only, not for use in diagnostic procedure. |
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