Estrogen Receptor beta (ESR2) Rabbit Polyclonal Antibody

CAT#: TA392941

ERβ (phospho-S105) polyclonal antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500~1:1000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide derived from human ERβaround the phosphorylation site of S105.
• Specificity: ERβ (phospho-S105) polyclonal antibody detects endogenous levels of Erβprotein around the phosphorylation site of S105.
• Formulation: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Concentration: 1mg/ml
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
• Stability: 1 year
• Predicted Protein Size: ~ 48, 60 kDa
• Gene Name: estrogen receptor 2
• Database Link:
  Entrez Gene 2100 Human
  UniProt ID Q92731
• Background: Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ERα and ERβ, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. ERα and ERβ have been shown to be differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ERα and ERβ may be regulated by distinct mechanisms even though they share many functional characteristics.
• Synonyms: ER-beta; ER-β; ESR2; ESTRB; Estrogen receptor beta; NR3A2; Nuclear receptor subfamily 3 group A member 2
• Note: For research use only, not for use in diagnostic procedure.