SSB Rabbit Polyclonal Antibody

CAT#: TA392943

SSB (phospho-S366) polyclonal antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500~1:1000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic phosphopeptide derived from human SSB around the phosphorylation site of Serine 366.
• Specificity: p-SSB (S366) polyclonal antibody detects endogenous levels of SSB protein only when phosphorylated at Serine 366.
• Formulation: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Concentration: 1mg/ml
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
• Stability: 1 year
• Predicted Protein Size: ~ 52 kDa
• Gene Name: Sjogren syndrome antigen B
• Database Link:
  Entrez Gene 6741 Human
  UniProt ID P05455
• Background: Ro/SSA is a ribonucleoprotein that binds to autoantibodies in 35 to 50% of patients with SLE and in up to 97% of patients with Sjogren syndrome. The Ro/SSA particle consists of a single immunoreactive protein noncovalently bound with one of four small RNA molecules. Most anti-Ro/SSA-positive sera have antibodies not only against the immunoreactive protein, but also against an Ro/SSA protein. The genes which encode the two proteins map to human chromosomes 11p15.5 and 1q31, respectively. La/SSB is an autoimmune RNA-binding protein that plays a role in the transcription of RNA polymerase III was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and SLE.
• Synonyms: Autoantigen La; LA; La; La autoantigen; La autoantigen homolog; La protein; La ribonucleoprotein; La ribonucleoprotein domain family member 3; LARP3; Lupus La antigen; Lupus La protein; Lupus La protein homolog; mRNA for autoantigen; Sjoegren syndrome type B antigen; Sjogren syndrome antigen B; SS-B; SS-B/La protein; SS B; SSB
• Note: For research use only, not for use in diagnostic procedure.