c Fos (FOS) Rabbit Polyclonal Antibody

CAT#: TA392945

c-Fos (phospho-S362) polyclonal antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500~1:1000 IHC: 1:50~1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic phosphopeptide derived from human c-Fos around the phosphorylation site of Serine 362.
• Specificity: p-c-Fos (S362) polyclonal antibody detects endogenous levels of c-Fos protein only when phosphorylated at Ser362
• Formulation: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Concentration: 1mg/ml
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
• Stability: 1 year
• Predicted Protein Size: ~ 62 kDa
• Gene Name: Fos proto-oncogene, AP-1 transcription factor subunit
• Database Link:
  Entrez Gene 2353 Human
  UniProt ID P01100
• Background: The c-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phospho-protein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family. Functional homologs of c-Fos include the Fra-1, Fra-2 and Fos B genes. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP-1 and CRE sites.
• Synonyms: Cellular oncogene fos; FOS; G0/G1 switch regulatory protein 7; G0S7; Proto-oncogene c-Fos
• Note: For research use only, not for use in diagnostic procedure.