Casein Kinase 1 alpha (CSNK1A1) Rabbit Polyclonal Antibody

CAT#: TA392955

Casein Kinase Iα (phospho-Y321) polyclonal antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500~1:1000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic phosphopeptide derived from human Casein Kinase Iα around the phosphorylation site of Tyrosine 321
• Specificity: p-Casein Kinase Iα (Y321) pAb detects endogenous levels of Casein Kinase Iα protein only when phosphorylated at Tyr321.
• Formulation: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Concentration: 1mg/ml
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
• Stability: 1 year
• Predicted Protein Size: ~ 34 kDa
• Gene Name: casein kinase 1 alpha 1
• Database Link:
  Entrez Gene 1452 Human
  UniProt ID P48729
• Background: Casein kinase I (also designated CKI) and casein kinase II (also designated CKII) compose a family of serine/threonine protein kinases which are present in all eukaryotes examined to date. CKI family members, which include CKIα, β, γ, e and δ, have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. CKII is usually expressed as a tetrameric complex consisting of either an α2β2 or an αα'β2 structure. The a catalytic subunit is stimulated by the β regulatory subunit, which undergoes autophosphorylation. CKII activity is high in the cytosol and nucleus of proliferating and differentiating cells. CKII is known to phosphorylate more than 100 different substrates including nuclear oncoproteins, transcription factors and enzymes involved in DNA metabolism.
• Synonyms: Casein kinase I isoform alpha; CK-Iα; CK1; CKI-alpha; CKI-α; CK Iα; CKIα; CSNK1A1
• Note: For research use only, not for use in diagnostic procedure.