LEF1 Rabbit Polyclonal Antibody

CAT#: TA392960

LEF-1 (phospho-S42) polyclonal antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500~1:1000
• Reactivities: Human, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic phosphopeptide derived from human LEF-1 around the phosphorylation site of Serine 42
• Specificity: p-LEF-1 (S42) pAb detects endogenous levels of LEF-1 protein only when phosphorylated at Ser42.
• Formulation: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Concentration: 1mg/ml
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
• Stability: 1 year
• Predicted Protein Size: ~ 53 kDa
• Gene Name: lymphoid enhancer binding factor 1
• Database Link:
  Entrez Gene 51176 Human
  UniProt ID Q9UJU2
• Background: This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.
• Synonyms: LEF-1; TCF1ALPHA; TCF7L3; TCF10
• Note: For research use only, not for use in diagnostic procedure.