Huntingtin (HTT) Rabbit Polyclonal Antibody

CAT#: TA397523

Huntington phospho S1181 Antibody

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: WB: 1ug/ml
  IHC: User Optimized
  ELISA: 1: 10,000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Anti-Huntingtin pS1181 affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the internal region of human Huntington disease protein.
• Specificity: Anti-Huntingtin pS1181 was affinity purified from monospecific antiserum by immunoaffinity chromatography and is directed against the phosphorylated form of the S1181 residue. A BLAST analysis was used to suggest cross-reactivity with human, mouse, and rat based on 100% sequence homology. Cross-reactivity with Huntington pS1181 from other sources has not been determined.
• Formulation: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
• Concentration: 1.0 mg/ml
• Conjugation: Unconjugated
• Storage: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
• Stability: Expiration date is one (1) year from date of receipt.
• Gene Name: huntingtin
• Database Link:
  Entrez Gene 3064 Human
  UniProt ID P42858
• Background: Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation of neuronal intracellular inclusions primarily in the striatum and cortex, leading to personality changes, motor impairment, and dementia. The Huntington’s disease protein is ~350kD in size and is localized in the brain. Anti-Huntington antibody is ideal for investigators interested in Neuroscience research.
• Synonyms: rabbit anti-Huntington pS1181 antibody, rabbit anti-Huntingtin pS1181 antibody, HD protein, HTT, Huntington Disease Protein, Huntington disease, IT15, LOMARS
• Note: Anti-HTT antibody is useful for ELISA, Immunohistochemistry, and Western Blot. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately ~350kDa corresponding to the appropriate cell lysate or extract.