PSMA7 Mouse Monoclonal Antibody [Clone ID: OTI2A7]

CAT#: TA500692

Anti-PSMA7 mouse monoclonal antibody, clone OTI2A7 (formerly 2A7)

Size: 30 ul 100 ul

Formulation: Standard Carrier Free


  View other "OTI2A7" antibodies (2)

USD 379.00

In Stock*

Size
    • 100 ul

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Specifications

Product Data
Clone Name OTI2A7
Applications WB
Recommended Dilution WB 1:1000
Reactivities Human, Mouse, Rat
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Full-length protein expressed in 293T cell transfected with human PSMA7 expression vector
Formulation PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 27.9 kDa
Gene Name proteasome 20S subunit alpha 7
Background The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. This particular subunit has been shown to interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. In addition, this subunit is involved in regulating hepatitis virus C internal ribosome entry site (IRES) activity, an activity essential for viral replication. This core alpha subunit is also involved in regulating the hypoxia-inducible factor-1alpha, a transcription factor important for cellular responses to oxygen tension. Multiple isoforms of this subunit arising from alternative splicing may exist but alternative transcripts for only two isoforms have been defined. A pseudogene has been identified on chromosome 9.
Synonyms C6; HEL-S-276; HSPC; RC6-1; XAPC7
Reference Data
Protein Families Druggable Genome, Protease
Protein Pathways Proteasome

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