HIPPI (IFT57) Mouse Monoclonal Antibody [Clone ID: OTI5B6]
CAT#: TA500906
Anti-IFT57 (HIPPI) mouse monoclonal antibody, clone OTI5B6 (formerly 5B6)
Size: 30 ul
Formulation: Carrier Free
Specifications
Product Data | |
Clone Name | OTI5B6 |
Applications | IHC, WB |
Recommended Dilution | WB 1:500, IHC 1:50 |
Reactivities | Human, Mouse, Rat |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Full length human recombinant protein of human IFT57 (NP_060480) produced in HEK293T cell. |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 0.53 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 48.9 kDa |
Gene Name | intraflagellar transport 57 |
Database Link | |
Background | Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator. |
Synonyms | ESRRBL1; HIPPI; MHS4R2 |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Huntington's disease |
Documents
Product Manuals |
FAQs |
SDS |
Resources
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