PKA R2 (PRKAR2A) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI4H8]

CAT#: TA501145AM

Anti-PRKAR2A (PKA R2 ) mouse monoclonal antibody, clone OTI4H8 (formerly 4H8), Biotinylated


USD 420.00

4 Weeks*

Size
    • 100 ug

Other products for "PRKAR2A"

Specifications

Product Data
Clone Name OTI4H8
Applications FC, IF, IHC, WB
Recommended Dilution WB 1:2000, IHC 1:50, IF 1:100, Flow: 1:100
Reactivities Human, Mouse, Rat
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Full length human recombinant protein of human PRKAR2A (NP_004148) produced in HEK293T cell.
Formulation PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 0.5 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Biotin
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 45.3 kDa
Gene Name protein kinase cAMP-dependent type II regulatory subunit alpha
Background cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).
Synonyms PKR2; PRKAR2
Reference Data
Protein Families Druggable Genome
Protein Pathways Apoptosis, Insulin signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.