Proteasome 20S beta 7 (PSMB7) Mouse Monoclonal Antibody [Clone ID: OTI4E3]
CAT#: TA504638
PSMB7 (Proteasome 20S beta 7 ) mouse monoclonal antibody, clone OTI4E3 (formerly 4E3)
Size: 30 ul
Formulation: Carrier Free
Specifications
Product Data | |
Clone Name | OTI4E3 |
Applications | IF, WB |
Recommended Dilution | WB 1:500~2000, IF 1:100 |
Reactivities | Human, Monkey, Mouse, Rat, Dog |
Host | Mouse |
Isotype | IgG2b |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 58-277 of human PSMB7(NP_002790) produced in E.coli. |
Formulation | PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 0.83 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 29.8 kDa |
Gene Name | proteasome subunit beta 7 |
Database Link | |
Background | The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon and proteolytic processing is required to generate a mature subunit. This subunit is not present in the immunoproteasome and is replaced by catalytic subunit 2i (proteasome beta 10 subunit). [provided by RefSeq] |
Synonyms | Z |
Reference Data | |
Protein Families | Druggable Genome, Protease |
Protein Pathways | Proteasome |
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