ITM2C Rabbit Polyclonal Antibody
Other products for "ITM2C"
Specifications
Product Data | |
Applications | ELISA, WB |
Recommended Dilution | WB 1:20000,ELISA 1:100-1:2000 |
Reactivities | Human |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | DNA immunization. This antibody is specific for the N Terminus Region of the target protein. |
Formulation | 20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0 |
Concentration | 0.96496 mg/ml |
Purification | The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody. |
Gene Name | integral membrane protein 2C |
Database Link | |
Background | ITM2C is a negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. ITM2C may also play a role in TNF-induced cell death and neuronal differentiation By similarity. |
Synonyms | BRI3; BRICD2C; E25; E25C; ITM3 |
Note | This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT |
Reference Data | |
Protein Families | Transmembrane |
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