Cytohesin 3 (CYTH3) Rabbit Polyclonal Antibody

CAT#: TA590844

Rabbit Polyclonal Cytohesin 3 Antibody

Product Images

ELISA: Cytohesin 3 Antibody

Specifications

Product Data

• Applications: ELISA
• Recommended Dilution: WB 1:5000~20000,ELISA 1:100-1:2000
• Reactivities: Human, Monkey, Mouse, Rat, Dog
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: DNA immunization. This antibody is specific for the N Terminus Region of the target protein.
• Formulation: 20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
• Concentration: 0.9mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: cytohesin 3
• Database Link:
  NP_004218
  Entrez Gene 19159 MouseEntrez Gene 116693 RatEntrez Gene 609100 DogEntrez Gene 717713 MonkeyEntrez Gene 9265 Human
  UniProt ID O43739
• Background: GRP1 (general receptor for 3-phosphoinositides) is composed of an N-terminal heptad repeat, an Arf exchange domain with homology to the yeast Sec7 protein, a PH domain, and a C-terminal polybasic region (1). The PH domain of GRP1 binds PtdIns(3, 4, 5)P3 with high affinity, but not PtdIns(3, 4)P2 or PtdIns(3)P, potentially making it a target for PI-3-kinase. Furthermore, GRP1 acts as a nucleotide exchange factor for the small GTP proteins of the ARF family (2). While GRP1 catalyses guanine-nucleotide exchange specifically on ARF5; other GRP1 homologues (ARNO and cytohesin-1) will only function on ARF6 and ARF3 respectively (3).
• Synonyms: ARNO3; cytohesin-3; GRP1; PSCD3
• Note: This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT

Reference Data

• Protein Families: Druggable Genome