Cathepsin B (CTSB) Rabbit Monoclonal Antibody [Clone ID: OTIR1C4]

CAT#: TA591040

Rabbit monoclonal anti-CATB antibody for SISCAPA, clone OTIR1C4

Specifications

Product Data

• Clone Name: OTIR1C4
• Applications: SISCAPA
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Synthetic peptide GQDHCGIESEVVAGIPR
• Formulation: Tissue culture buffer containing 1% BSA and 0.02% Sodium azide
• Concentration: Lot dependent; please refer to CoA along with shipment
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 37.82 kDa
• Gene Name: cathepsin B
• Database Link:
  NP_680093
  Entrez Gene 1508 Human
  UniProt ID P07858
• Background: This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Nov 2015]
• Synonyms: APPS; CPSB; RECEUP

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Antigen processing and presentation, Lysosome