Chk1 (CHEK1) Rabbit Monoclonal Antibody [Clone ID: OTIR3G7]

CAT#: TA591044

Rabbit monoclonal anti-CHK1 antibody for SISCAPA, clone OTIR3G7

Specifications

Product Data

• Clone Name: OTIR3G7
• Applications: SISCAPA
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Synthetic peptide HIQSNLDFSPVNSASSEENVK
• Formulation: Tissue culture buffer containing 1% BSA and 0.02% Sodium azide
• Concentration: Lot dependent; please refer to CoA along with shipment
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 54.4 kDa
• Gene Name: checkpoint kinase 1
• Database Link:
  NP_001265
  Entrez Gene 12649 MouseEntrez Gene 140583 RatEntrez Gene 1111 Human
  UniProt ID O14757
• Background: The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
• Synonyms: CHK1

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Stem cell - Pluripotency
• Protein Pathways: Cell cycle, p53 signaling pathway