Vimentin (VIM) Mouse Monoclonal Capture Antibody [Clone ID: OTI5C10]

CAT#: TA600392

VIM mouse monoclonal antibody, clone OTI5C10


  View other "OTI5C10" antibodies (4)

USD 447.00

2 Weeks*

Size
    • 100 ul

Product Images

Specifications

Product Data
Clone Name OTI5C10
Applications ELISA
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Full length human recombinant protein of human VIM (NP_003371) produced in E.coli.
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 0.5mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Predicted Protein Size 53.5 kDa
Gene Name vimentin
Background Vimentin (VIM) is a structural protein that in humans is encoded by the VIM gene. A vimentin monomer has a central α-helical domain, capped on each end by non-helical amino (head) and carboxyl (tail) domains. Two monomers are likely co-translationally expressed in a way that facilitates their formation of a coiled-coil dimer, which is the basic subunit of vimentin assembly. It is a type III intermediate filament (IF) protein that is expressed in mesenchymal cells. Intermediate filaments, along with tubulin-based microtubules and actin-based microfilaments, comprises the cytoskeleton. Vimentin is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. Since vimentin is the major cytoskeletal component of mesenchymal cells, it is often used as a marker of mesenchymally-derived cells or cells undergoing an epithelial-to-mesenchymal transition during both normal development and metastatic progression. Vimentin has been used as an immunohistochemical tumor marker of sarcoma, renal cell carcinoma, endometrial cancer, lung carcinoma, lymphoma, leukemia, and melanoma.
Reference Data
Protein Families ES Cell Differentiation/IPS

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.