Cytokeratin 19 (KRT19) Mouse Monoclonal Capture Antibody [Clone ID: OTI9A9]

CAT#: TA600573

KRT19 mouse monoclonal antibody, clone OTI9A9

Specifications

Product Data

• Clone Name: OTI9A9
• Applications: ELISA
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human recombinant protein fragment of human KRT19 (NP_002267) produced in E.coli.
• Formulation: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 0.5mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Predicted Protein Size: 43.9 kDa
• Gene Name: keratin 19
• Database Link:
  NP_002267
  Entrez Gene 3880 Human
  UniProt ID P08727
• Background: Keratin-19 (KRT19) also known as keratin, type I cytoskeletal 19, cytokeratin-19 (CK-19), or CYFRA 21-1, is a 40 kDa protein that in humans is encoded by the KRT19 gene. Keratin 19 is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 19 is a type I keratin. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. KRT19 is the most used marker for the RT-PCR-mediated detection of tumor cells disseminated in lymph nodes, peripheral blood, and bone marrow of breast cancer patients. There is a positive correlation between higher expression of KRT19 in some kind of cancers and worse patient survival, where it serves as a diagnostic or prognostic biomarker.
• Synonyms: CK19; K1CS; K19