Myeloperoxidase (MPO) Mouse Monoclonal Capture Antibody [Clone ID: OTI4G10]

CAT#: TA600575

MPO mouse monoclonal antibody, clone OTI4G10

Specifications

Product Data

• Clone Name: OTI4G10
• Applications: ELISA
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Full length recombinant protein of human MPO (NP_000241) produced in Baculovirus-Insect cell.
• Formulation: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 0.5mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Predicted Protein Size: 83.7 kDa
• Gene Name: myeloperoxidase
• Database Link:
  NP_000241
  Entrez Gene 4353 Human
  UniProt ID P05164
• Background: Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the MPO gene. MPO protein is a 150-kDa cationic heterotetramer consisting of two 15-kDa light chains and two variable-weight glycosylated heavy chains bound to a prosthetic heme group, arranged as a homodimer of heterodimers. MPO is most abundantly expressed in neutrophil granulocytes, and produces hypohalous acids to carry out their antimicrobial activity, including hypochlorous acid. It is a lysosomal protein stored in azurophilic granules of the neutrophil and released into the extracellular space during degranulation. Myeloperoxidase deficiency is a hereditary deficiency of the enzyme, which predisposes to immune deficiency. Recent studies have reported an association between elevated myeloperoxidase levels and the severity of coronary artery disease, and elevated MPO levels increased the risk for cardiovascular mortality. It has also been suggested that myeloperoxidase plays a significant role in the development of the atherosclerotic lesion and rendering plaques unstable. MPO could serve as a sensitive predictor for myocardial infarction.

Reference Data

• Protein Families: Druggable Genome