CA12 Biotinylated Mouse Monoclonal Detection Antibody [Clone ID: OTI3F1]

CAT#: TA700451

CA12 biotinylated mouse monoclonal antibody, clone OTI3F1


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USD 447.00

2 Weeks*

Size
    • 100 ul

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Specifications

Product Data
Clone Name OTI3F1
Applications ELISA
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Full length human recombinant protein of human CA12(NP_001209) produced in HEK293T cell.
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 0.5mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Predicted Protein Size 39.5 kDa
Gene Name carbonic anhydrase 12
Background Carbonic anhydrase 12 (CA12) is an enzyme that in humans is encoded by the CA12 gene. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Loss of function mutations in the CA12 gene result in defects in fluids and carbonate secretions, which is involved in cystic fibrosis-like syndrome with normal cystic fibrosis transmembrane conductance regulator (CFTR) protein levels, pancreatitis, Sjögren's syndrome and Xerostomia or dry mouth syndrome. It has been shown that CA12 expression is associated with a better prognosis in an unselected series of invasive breast carcinoma patients. Moreover, serum CA12 levels have been found significantly higher in lung cancer patients than in healthy controls, supporting that CA12 may be a promising diagnostic marker for lung cancer.
Synonyms CA-XII; CAXII; HsT18816; T18816
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Nitrogen metabolism

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