HSD17B13 Biotinylated Rabbit Monoclonal Detection Antibody [Clone ID: OTIR13E1]

CAT#: TA700566

HSD17B13 biotinylated rabbit monoclonal antibody, clone OTIR13E1


USD 531.00

2 Weeks*

Size
    • 100 ul

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Other products for "HSD17B13"

Specifications

Product Data
Clone Name OTIR13E1
Applications ELISA
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Monoclonal
Immunogen Full length human recombinant protein of human HSD17B13 produced in HEK293T cell.
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 0.5mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Predicted Protein Size 33.7 kDa
Gene Name hydroxysteroid 17-beta dehydrogenase 13
Background 17β-Hydroxysteroid dehydrogenase type 13 (HSD17B13) is an enzyme that in humans is encoded by the HSD17B13 gene. HSD17B13 is a 300-amino-acid protein that is localized on lipid droplet. The RNA expression of HSD17B13 is highly restricted to the liver, specifically in hepatocytes but not other cell types in the liver. HSD17B13 is involved in various metabolic processes, including steroid hormones, fatty acids, cholesterol, and bile acids. HSD17B13 has been reported to catalyze multiple substrates including steroids, bioactive lipids including leukotriene B4 and 12(R)-hydroxyeicosatetraenoic acid, and retinol. HSD17B13 enzymatic activity attributes to hepatic cell injury, inflammation, and fibrosis, chronically leading to the development of alcoholic liver disease (ALD), nonalcoholic steatohepatitis (NASH), cirrhosis, and even hepatocellular carcinoma (HCC). HSD17B13 expression is significantly upregulated in patients and mice with non-alcoholic fatty liver disease (NAFLD). Hepatic overexpression of HSD17B13 promotes lipid accumulation in the liver. HSD17B13 has potential as a biomarker of advanced liver disease, such as non-alcoholic steatohepatitis (NASH) and liver cancer.
Synonyms HMFN0376; NIIL497; SCDR9; SDR16C3
Reference Data
Protein Families Druggable Genome, Secreted Protein, Transmembrane

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.